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Association between killer cell immunoglobulin‐like receptor 2DS5 gene with essential hypertension in the Chinese Han patients
Author(s) -
Wang A. L.,
Jiang B.,
Qian X. Y.,
Zhang Q.,
Peng H.,
Zhang Y. H.
Publication year - 2017
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12342
Subject(s) - odds ratio , immunology , gene , primer (cosmetics) , essential hypertension , pathogenesis , immune system , antibody , receptor , biology , medicine , genetics , blood pressure , chemistry , organic chemistry
Summary Hypertension has been suggested to be mediated by immunity and inflammation. As immune system genes, killer cell immunoglobulin‐like receptors ( KIR s) genes play an important role in the pathogenesis of autoimmune diseases. We conducted a community population‐based case–control study to analyse associations between KIR genes and hypertension. KIR genes were genotyped using sequence‐specific primer polymerase chain reaction in 380 unrelated essential hypertensives and 527 normotensives. The frequencies of KIR 2 DS 5 gene were significantly decreased in participants with high high‐sensitivity C‐reactive protein (hs CRP ) compared with participants with low hs CRP (17.02% vs 34.08%, p = .016). The presence of KIR 2 DS 5 gene was independently associated with decreased risk of hypertension (odds ratio = 0.62; 95% confidence interval: 0.43–0.89), after adjusted for conventional risk factors, hs CRP and other KIR genes. We found that participants with KIR 2 DS 5 gene had a decreased risk of hypertension compared with participants without KIR 2 DS 5 gene. Our findings suggested that KIR 2 DS 5 gene may be protective against hypertension.