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HLA ‐G gene 14‐bp deletion variant protects Iranian subjects against chronic hepatitis B infection
Author(s) -
Eskandari E.,
Dahmardeh T.,
Safdari V.,
Khosravi S.,
Pahlevani E.
Publication year - 2017
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12337
Subject(s) - genotype , allele , human leukocyte antigen , polymerase chain reaction , biology , immunology , allele frequency , gene , medicine , genetics , antigen
Summary To investigate whether 14‐bp Ins/Del polymorphism in HLA ‐G gene is associated with the risk of chronic hepatitis B ( CHB ) infection. This study was performed on a total of 396 individuals including 199 CHB patients and 197 healthy subjects from a south‐east Iranian population. We genotyped 14‐bp Ins/Del polymorphism in the HLA ‐G gene using polymerase chain reaction method. The results of our study revealed that the HLA ‐G 14‐bp deletion polymorphism was associated with a reduced risk of CHB at both allele and genotypic levels. The 14‐bp Del allele and Ins/Del genotype were more frequent in control group than in CHB patients (37% vs 28% for Del allele with OR = 0.68 and p ‐value = .015; 73% vs 52% for Ins/Del genotype with OR = 0.43 and p ‐value = .001) and both were protective factors against CHB . However, no difference was found in the distribution of HLA ‐G 14‐bp genotypes among subjects with varied levels of HBV DNA or hepatic enzymes ( p > .05). Our findings, for the first time, suggest that the HLA ‐G 14‐bp Ins/Del polymorphism may be a marker for genetic susceptibility to CHB infection.