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Promoter polymorphisms of the TIM ‐4 gene are correlated with disease activity in patients with systemic lupus erythematosus
Author(s) -
Liu B.,
Liu W.,
Wang R.,
Shu Q.,
Zhang X.,
Fan X.,
Zhang Q.,
Liang X.,
Ma C.,
Gao L.
Publication year - 2017
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12316
Subject(s) - genotype , single nucleotide polymorphism , immunology , immune system , snp , gene , medicine , lupus erythematosus , biology , genetics , antibody
Summary Although the TIM gene family plays important roles in immune responses, little is known about TIM regulation in the development of systemic lupus erythematosus ( SLE ). This study aimed to investigate the association of two TIM ‐4 single nucleotide polymorphisms ( SNP s) rs6874202 (−1419G>A) and rs62382402 (−1609G>A) with SLE susceptibility in a Chinese Han population. The results showed no significant differences between patients with SLE and control group for rs6874202 and rs62382402 ( p = .72, .53 respectively). However, the anti‐ds DNA levels in serum from SLE patients with GG genotype of TIM ‐4 gene at ‐1419 site were significantly higher than those with GA and AA genotype ( p = .0335), and C3 levels of SLE patients with GG and GA genotype were much lower than those with AA genotypes ( p = .0187). Moreover, the apoptotic cell levels of SLE patients with AA and GG genotypes were significantly higher than those with GA genotypes in patients with SLE ( p = .0393). In addition, the C3 concentration of SLE patients with the GG genotype of TIM ‐4 gene at ‐1609 site was found to be significantly higher than those with the GA genotype ( p = .0129). The results imply that GG genotype of the TIM ‐4 gene at ‐1419 site might be associated with the disease activity of SLE .