Premium
Identification and characterization a novel HLA ‐A allele, A*02:355, by sequence‐based typing in a Chinese potential donor
Author(s) -
Nie XM.,
Zhang Y.,
Qiao WB.,
Zhu CF.,
Zhao YR.
Publication year - 2017
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12302
Subject(s) - allele , typing , sequence (biology) , human leukocyte antigen , genetics , peptide sequence , biology , identification (biology) , amino acid substitution , gene , antigen , mutation , botany
Summary The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.