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Polymorphisms in Toll‐like receptor 3 are associated with asthma‐related phenotypes in the Chinese Han patients
Author(s) -
Zhang Q.,
Fu X. L.,
Qian F. H.,
Cao Q.,
Mao Z. D.,
Bai J. L.,
Du Q.,
Shi Y.
Publication year - 2016
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12290
Subject(s) - asthma , immunology , single nucleotide polymorphism , snp , medicine , eosinophil , pathogenesis , genotyping , phenotype , genotype , allergy , biology , genetics , gene
Summary Toll‐like receptor ( TLR ) 3 mediates antivirus immunity and is involved in asthma exacerbation and development. However, the genetic association between TLR 3 and asthma remains unclear. This study aimed to evaluate the effects of polymorphisms within TLR 3 on asthma risk and asthma‐related phenotypes in the Chinese Han population. A total number of 462 unrelated adult patients with asthma and 398 healthy volunteers were enrolled in this study. The genotypes of tagging single nucleotide polymorphisms ( SNP s) in TLR 3 gene were determined using multiplex SN aPshot SNP genotyping assays. Case–control and case‐only studies were used to assess any links with asthma and asthma‐related phenotypes. The results showed that the genetic variants in TLR 3 were associated with asthma‐related phenotypes, including eosinophil counts, serum immunoglobulin E levels and lung function. However, there was no obvious association between the TLR 3 SNP s and asthma susceptibility or asthma severity. TLR 3 polymorphisms may play a considerable role in the pathogenesis of asthma. It will help in better understanding the pathogenesis of asthma and development of more effective strategies for the prevention, prediction and treatment of asthma.