Characterization of a novel   MICA   allele,   MICA *012:05 , by cloning and sequencing | Zendy

Wang W. Y. | Zendy; Tian W. | Zendy; Wang F. | Zendy; Zhu F. M. | Zendy; Li L. X. | Zendy

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Characterization of a novel MICA allele, MICA *012:05 , by cloning and sequencing

Author(s) -

Wang W. Y.,

Tian W.,

Wang F.,

Zhu F. M.,

Li L. X.

Publication year - 2016

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12275

Subject(s) - mica , cloning (programming) , allele , exon , haplotype , polymerase chain reaction , microbiology and biotechnology , genetics , biology , gene , paleontology , computer science , programming language

Summary A new MICA allelic variant, MICA *012:05 , has been identified in a Chinese Mongolian population. Following polymerase chain reaction–sequence‐based typing ( PCR ‐ SBT ), this new allele was further confirmed by cloning and sequencing. MICA *012:05 was linked to an HLA ‐A*24‐C*01‐B*55:02‐ DRB 1*09 haplotype. MICA *012:05 differs from MICA *012:01 by a single synonymous C to T substitution at nucleotide position 269 in exon 3.

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