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The possible role of the tumour necrosis factor polymorphisms and human leucocyte antigens in the development of prostate cancer
Author(s) -
Stingl Jankovic K.,
Hudolin T.,
Kastelan Z.,
Zunec R.,
Grubic Z.
Publication year - 2016
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12262
Subject(s) - allele , prostate cancer , medicine , perineural invasion , tumor necrosis factor alpha , prostate , etiology , human leukocyte antigen , genetic predisposition , prostatitis , immunology , antigen , cancer , oncology , biology , gene , disease , genetics
Summary The cause of prostate cancer ( PC ), one of the most common cancers found among ageing men, remains unclear, but genetic predisposition is believed to play a major role in its aetiology. The aim of the study was to examine HLA genes polymorphism and TNF polymorphisms in PC development. Patients diagnosed with PC ( N = 113) and 150 healthy individuals were tested for HLA ‐A, HLA ‐B and HLA ‐ DRB 1 genes and for TNF a, TNF b and TNF d microsatellites. The comparison of patients and controls revealed a positive association of HLA ‐ DRB 1*12, TNF a2 and TNF b5, and a negative association of HLA ‐ DRB 1*13 and TNF b4 with PC . A division of patients into groups according to age, pre‐operative PSA level, Gleason score ( GS ) and involvement of prostatic capsule, seminal vesicles or bladder neck and perineural invasion of PC demonstrated the following: a positive correlation of HLA ‐ DRB 1*12 and a negative correlation of HLA ‐ DRB 1*13 with younger patients (<65 years), GS > 7 and the positive association of prostatic capsule, seminal vesicles, bladder neck and perineural invasion of PC ; TNF b4 allele's negative association with older patients displaying higher PSA levels, higher GS and positive surrounding tissue involvement; positive association of TNF b5 allele for both older and younger patients. Investigation of HLA genes and TNF microsatellites demonstrated a possible role of HLA ‐ DRB 1 and TNF regions in PC aetiology.