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Increased CD 1D polymorphism: identification of two novel alleles, CD 1D*03 and *04, in individuals from M orocco
Author(s) -
Aureli A.,
Oumhani K.,
Del Beato T.,
Di Rocco M.,
Tessitore A.,
El Aouad R.,
Piancatelli D.
Publication year - 2015
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12210
Subject(s) - methionine , exon , amino acid , biology , allele , genetics , cysteine , threonine , transition (genetics) , arginine , microbiology and biotechnology , biochemistry , gene , phosphorylation , serine , enzyme
Summary Two novel CD 1D alleles were identified in unrelated individuals from Morocco. They differ each from the common CD 1D*01 allele by one nucleotide substitution in exon 2 resulting in one amino acid change in the G‐ ALPHA 1‐ LIKE domain. According to the IMGT unique numbering for G domain, CD 1D*03 has one nucleotide transition c136 > t in codon 46, with an arginine‐to‐cysteine amino acid change (R46 > C) in the D‐ STRAND , whereas CD 1D*04 has one transition c98 > t in codon 33, with a threonine‐to‐methionine amino acid change (T33 > M) in the C‐ STRAND . This suggests that CD 1D is more polymorphic than previously assumed.
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