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ERAP 1 variants are associated with ankylosing spondylitis in East Asian population: a new Chinese case–control study and meta‐analysis of published series
Author(s) -
Chen C.,
Zhang X.
Publication year - 2015
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12196
Subject(s) - meta analysis , ankylosing spondylitis , medicine , genotyping , population , genetics , demography , biology , genotype , environmental health , sociology , gene
Summary Endoplasmic reticulum aminopeptidase 1 (ERAP1) has been confirmed to be associated with ankylosing spondylitis (AS) in Caucasian. However, whether they are associated with AS in East Asian population remains unidentified. We investigated this relationship by a new Chinese case–control study and a meta‐analysis of published series. 368 cases and 460 controls were recruited in the Chinese case–control study. Genotyping was completed using the chip‐based matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry. Allelic associations were analysed using contingency tables. In the meta‐analysis, up to 2748 cases and 2774 controls from seven different studies and the new Chinese study were combined using Review Manager software version 5.1.1. Mantel–Haenszel or Inverse Variance test was used to calculate fixed or random‐effects pooled OR s. In the new Chinese study, strong association with AS was observed for marker rs10050860, rs27434 and rs1065407 at P value of <0.001. Moderate association was observed for rs30187 at P value of <0.01, while no association was observed for rs27044 ( P = 0.37) and rs2287987 ( P = 0.23). The meta‐analysis showed that rs27037 and rs30187 were strongly associated with AS ( P < 0.00001). Significant association was also observed for rs27434 ( P = 0.001). No association was shown for rs27044 ( P = 0.70). We concluded that ERAP 1 variants are associated with AS in East Asian population, indicating a common pathogenic mechanism for AS in East Asians and Caucasians.