A group‐specific sequence‐based typing approach for  HLA ‐ DQA 1 | Zendy

Lemin A. J. | Zendy; Johnson J. | Zendy; Darke C. | Zendy

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A group‐specific sequence‐based typing approach for HLA ‐ DQA 1

Author(s) -

Lemin A. J.,

Johnson J.,

Darke C.

Publication year - 2015

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12171

Subject(s) - typing , human leukocyte antigen , concordance , sequence (biology) , computational biology , biology , genetics , computer science , antigen

Summary An HLA ‐ DQA 1 sequence‐based typing method reliant upon group‐specific amplification to achieve an unambiguous second‐field DQA 1 typing assignment is presented. Method validation, using 51 reference DNA samples covering 21 different DQA 1 alleles, showed 100% concordance with the reference types. This typing strategy has several important uses including identifying DQA 1 mismatches in kidney donor/recipient pairs to inform patient DQ antibody assignments.

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