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TLR 8 gene polymorphism and association in bacterial load in southern P unjab of P akistan: an association study with pulmonary tuberculosis
Author(s) -
Bukhari M.,
Aslam M. A.,
Khan A.,
Iram Q.,
Akbar A.,
Naz A. G.,
Ahmad S.,
Ahmad M. M.,
Ashfaq U. A.,
Aziz H.,
Ali M.
Publication year - 2015
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12170
Subject(s) - allele , genotype , biology , mycobacterium tuberculosis , nonsynonymous substitution , tuberculosis , immunology , population , snp , polymorphism (computer science) , genetics , gene , single nucleotide polymorphism , medicine , pathology , environmental health , genome
Summary Only 5–10% of people infected with M ycobacterium tuberculosis develop active tuberculosis which suggests a role of genetic variation in host immunity. Genetic variants in TLR s are potential indicator for host susceptibility and outcome of several diseases. We explored the association of nonsynonymous genetic variants ( M et1 V al) with T oll‐like receptor 8 in Pakistani population. Genotypic and allelic distribution of TLR 8 polymorphism (rs3764880) in patients with TB and healthy donors from different areas of southern P unjab, P akistan, was determined. Results provide that our population is highly influenced by TLR 8 M et1 V al SNP for TB , and G allele appeared to increase TB susceptibility. Mutant genotype GG or G /− and G allele was significantly higher among all the categories of cases than in controls. Among different levels of bacillary load and genotypes, GG or G /− and G allele significantly supports the incidence of 2 + class for bacterial load.