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Next generation sequencing: considering the ethics
Author(s) -
Davey S.
Publication year - 2014
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12155
Subject(s) - biobank , confidentiality , informed consent , dna sequencing , research ethics , ethical issues , engineering ethics , psychology , medicine , biology , political science , bioinformatics , alternative medicine , genetics , engineering , law , pathology , dna
Summary This review article discusses some of the ethical challenges posed by next generation sequencing ( NGS ), both in the clinical and research setting. Concerns such as how to deal with unexpected results apply equally to conventional techniques. However, these incidental findings are far more likely with the use of NGS and whole genome sequencing. Whilst the lines of responsibility are better defined in the clinical environment, disclosure of such findings in the research setting is less clear. Recruitment of volunteers for public biobank research, in particular, also raises questions regarding consent and confidentiality.