Prevalence of  HLA ‐ DQA 1 alleles and haplotypes in blood donors resident in  W ales | Zendy

Lemin A. J. | Zendy; Darke C. | Zendy

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Prevalence of HLA ‐ DQA 1 alleles and haplotypes in blood donors resident in W ales

Author(s) -

Lemin A. J.,

Darke C.

Publication year - 2014

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12154

Subject(s) - allele , human leukocyte antigen , haplotype , genetics , biology , population , immunology , antigen , medicine , gene , environmental health

Summary Two hundred and fifty‐four normal blood donors, from a largely UK European population, were sequence‐based typed for HLA ‐A, HLA ‐B, HLA ‐C, HLA ‐ DRB 1, HLA ‐ DQA 1 and HLA ‐ DQB 1. The fit to H ardy– W einberg expectations was good for all loci (all P values >0.5). Fifteen DQA 1 alleles were identified to the second field. DQA 1 carriage, allele and DQA 1– DQB 1 and DRB 1– DQA 1– DQB 1 haplotype frequencies, linkage disequilibria and related values are presented.

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