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Identification and characterization of a novel HLA ‐A allele, HLA ‐A*68:105, by genomic sequencing
Author(s) -
Curcio M.,
Presciuttini S.,
Sciarrino R.,
Fornaciari S.,
Mariotti M. L.,
Scatena F.
Publication year - 2014
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12153
Subject(s) - intron , exon , allele , human leukocyte antigen , genetics , microbiology and biotechnology , start codon , genomic dna , biology , typing , nucleotide , gene , antigen
Summary A novel HLA ‐A allele, HLA ‐A*68:105, was detected by sequence‐based typing ( SBT ) in an Italian bone marrow donor. It differs from HLA ‐A*68:01:02 at five nucleotides, three intronic, nt 699 T‐>G (intron 2), nt 705 T‐>C (intron 2) and nt 2770 G‐>A (intron 7), and two located in exon 3, at positions 726 A‐G (codon 94 Ile‐>Val) and 733 T‐G (codon 97 Arg‐>Met), respectively.