Identification and characterization of a novel  HLA ‐A allele,  HLA ‐A*68:105, by genomic sequencing | Zendy

Curcio M. | Zendy; Presciuttini S. | Zendy; Sciarrino R. | Zendy; Fornaciari S. | Zendy; Mariotti M. L. | Zendy; Scatena F. | Zendy

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Identification and characterization of a novel HLA ‐A allele, HLA ‐A*68:105, by genomic sequencing

Author(s) -

Curcio M.,

Presciuttini S.,

Sciarrino R.,

Fornaciari S.,

Mariotti M. L.,

Scatena F.

Publication year - 2014

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12153

Subject(s) - intron , exon , allele , human leukocyte antigen , genetics , microbiology and biotechnology , start codon , genomic dna , biology , typing , nucleotide , gene , antigen

Summary A novel HLA ‐A allele, HLA ‐A*68:105, was detected by sequence‐based typing ( SBT ) in an Italian bone marrow donor. It differs from HLA ‐A*68:01:02 at five nucleotides, three intronic, nt 699 T‐>G (intron 2), nt 705 T‐>C (intron 2) and nt 2770 G‐>A (intron 7), and two located in exon 3, at positions 726 A‐G (codon 94 Ile‐>Val) and 733 T‐G (codon 97 Arg‐>Met), respectively.

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