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HLA ‐ DRA is associated with P arkinson's disease in I ranian population
Author(s) -
Jamshidi J.,
Movafagh A.,
Emamalizadeh B.,
Zare Bidoki A.,
Manafi A.,
Ghasemi Firouzabadi S.,
Shahidi G.A.,
Kazeminasab S.,
Petramfar P.,
Fazeli A.,
Motallebi M.,
MortazaviTabatabaei S. A.,
Kowsari A.,
Jafarian Z.,
Darvish H.
Publication year - 2014
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12151
Subject(s) - snp , allele , human leukocyte antigen , genetic association , genetics , single nucleotide polymorphism , disease , genome wide association study , population , biology , genomic dna , parkinson's disease , medicine , genotype , gene , antigen , environmental health
Summary The rs3129882, a noncoding variant in HLA ‐ DR , was found to be associated with Parkinson's disease ( PD ) using several genome‐wide association studies. The aim of this replication study was to explore the relationship between this variant and PD in Iranian population. Genomic DNA was extracted from peripheral blood samples, and the rs3129882 SNP was genotyped using a PCR ‐ RFLP method in 520 PD patients and 520 healthy Iranian controls. Significant differences were found in allele frequencies between patients and controls ( χ 2 = 4.64, P = 0.031). Under additive and dominant models, the association of the SNP with PD risk is significant, where the A allele was observed to be protective. The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian. This is the first study reporting such an association in this population. More replication studies are needed to confirm this data.