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Polymorphisms in the TNF ‐ α , TNFR 1 gene and risk of rheumatoid arthritis in Chinese Han population
Author(s) -
Li F.,
Gao J.,
Sokolove J.,
Xu J.,
Zheng J.,
Zhu K.,
Pan Z.
Publication year - 2014
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12148
Subject(s) - rheumatoid arthritis , genotype , allele , immunology , snp , autoantibody , high resolution melt , tumor necrosis factor alpha , pathogenesis , medicine , arthritis , polymorphism (computer science) , biology , single nucleotide polymorphism , gene , genetics , antibody
Summary Recent advances have highlighted a major genetic contribution to the pathogenesis of rheumatoid arthritis ( RA ).The aim of this study was to investigate whether polymorphisms of TNF ‐ α (rs1800630, rs1800629) and TNFR 1 (rs767455) were associated with susceptibility to and clinical outcome of RA in Chinese Han population. The target gene polymorphisms were genotyped in 256 patients with RA and 331 healthy controls using a high resolution melting ( HRM ) method. ESR , CRP , RF anti‐ CCP and anti‐ GPI level were also assayed and compared in genotypes of each polymorphism. Significant difference was observed in the genotype distributions and allele frequencies of TNF ‐ α rs1800629 ( P = 0.001, P < 0.001, respectively) between patients with RA and controls. There is no evidence to suggest an association between genotypes of the 3 SNP s according to age, gender, disease duration, DAS 28 and serum level of autoantibodies. This study identifies a potentially important role for TNF ‐ α rs1800629 polymorphisms in the susceptibility to RA .However, further studies in larger cohorts are required.