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Two novel alleles HLA ‐ DRB 1*11:150 and HLA ‐ DRB 1*14:145 identified in Saudi individuals
Author(s) -
Fakhoury H. A.,
Cereb N.,
Jawdat D.,
Al Jumah M.,
Alaskar A. S.,
Hajeer A. H.
Publication year - 2014
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12133
Subject(s) - threonine , exon , allele , human leukocyte antigen , arginine , amino acid , genetics , amino acid substitution , biology , microbiology and biotechnology , gene , mutation , serine , antigen , phosphorylation
Summary Two new HLA ‐ DRB 1 alleles were identified by sequence‐based typing method ( SBT ) in 1100 participants in the Saudi Stem Cell Donor Registry. HLA ‐ DRB 1*11:150 differs from HLA ‐ DRB 1*11:01:01G by a single C to A substitution at nucleotide position 5580 in exon 2, resulting in an amino acid change from alanine to glutamic acid at position 74. HLA ‐ DRB 1*14:145 differs from HLA ‐ DRB 1*14:04 by a C to G substitution at nucleotide position 5511 in exon 2, resulting in an amino acid change from threonine to arginine at position 51.