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Polymorphisms of inflammation‐related genes and colorectal cancer risk: a population‐based case–control study in C hina
Author(s) -
Yu Y.,
Zheng S.,
Zhang S.,
Jin W.,
Liu H.,
Jin M.,
Chen Z.,
Ding Z.,
Wang L.,
Chen K.
Publication year - 2014
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12119
Subject(s) - multifactor dimensionality reduction , colorectal cancer , single nucleotide polymorphism , genotype , medicine , logistic regression , oncology , case control study , population , cancer , gastroenterology , gene , genetics , biology , environmental health
Summary The previous studies found that chronic inflammation related to an increased risk of colorectal cancer ( CRC ). This study aims to explore the associations of polymorphisms in inflammation‐related genes ( IL 10, IL 10 RA , IL 6R, TNFRSF 1A, TNFRSF 1B, LTA and IL 4) and their interactions with the risk of colorectal cancer among Chinese population. A population‐based case–control study including 299 cases and 296 controls was conducted from January 2001 to December 2009. Multivariate unconditional logistic regression was used to analyse the association of nine SNP s in inflammation‐related genes with the risk of CRC , colon cancer and rectal cancer, respectively. Generalized multifactor dimensionality reduction ( GMDR ) was implemented to explore the gene–gene interactions among all SNP s on CRC . A decreased risk of colorectal cancer in subjects with rs1800872 AC genotype of IL 10 ( OR = 0.643, 95% CI = 0.453, 0.912) or AC / CC genotype ( OR = 0.636, 95% CI = 0.457, 0.885) was observed, compared with those with AA genotype. Meanwhile, similar associations were observed between rs1800872 and rectal cancer. Additionally, in rs1061624 of TNFRSF 1B gene, AG genotype ( OR =0.566; 95% CI = 0.362, 0.885) and AG / GG genotype ( OR =0.638; 95% CI =0.420, 0.971) were significantly associated with a decreased risk of rectal cancer, respectively. Our findings indicated that mutants in IL 10 and TNFRSF 1B genes may change the CRC risk. However, there is no interaction between inflammation‐related genes on CRC risk.