Four novel  HLA  alleles,  DRB 1*04:11:03,  DRB 1*10:05,  DRB 1*15:94 and  DRB 1*16:22, identified in  B razilian individuals | Zendy

FabretiOliveira R. A. | Zendy; Nascimento E. | Zendy; Oliveira C. K. F. | Zendy; Vale E. M. G. | Zendy; Vilela B. | Zendy; Santos M. A. | Zendy

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Four novel HLA alleles, DRB 1*04:11:03, DRB 1*10:05, DRB 1*15:94 and DRB 1*16:22, identified in B razilian individuals

Author(s) -

FabretiOliveira R. A.,

Nascimento E.,

Oliveira C. K. F.,

Vale E. M. G.,

Vilela B.,

Santos M. A.

Publication year - 2014

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12091

Subject(s) - allele , biology , human leukocyte antigen , single nucleotide polymorphism , typing , microbiology and biotechnology , genetics , antigen , gene , genotype

Summary Four novel human leucocyte antigen ( HLA ) class II alleles were identified by sequencing‐based typing ( SBT ) and analysis of the closest‐matching alleles from volunteer subjects from the B razilian B one M arrow D onor R egister ( REDOME , B razil). The new HLA alleles discovered include DRB 1*04:11:03, DRB 1*10:05, DRB 1*15:94 and DRB 1*16:22. Three of the novel alleles had single‐nucleotide substitution polymorphisms when compared to their most homologous allele. Of these, one harboured a single‐nucleotide polymorphism ( SNP ) identified as a silent substitution.

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