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Four novel HLA alleles, DRB 1*04:11:03, DRB 1*10:05, DRB 1*15:94 and DRB 1*16:22, identified in B razilian individuals
Author(s) -
FabretiOliveira R. A.,
Nascimento E.,
Oliveira C. K. F.,
Vale E. M. G.,
Vilela B.,
Santos M. A.
Publication year - 2014
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12091
Subject(s) - allele , biology , human leukocyte antigen , single nucleotide polymorphism , typing , microbiology and biotechnology , genetics , antigen , gene , genotype
Summary Four novel human leucocyte antigen ( HLA ) class II alleles were identified by sequencing‐based typing ( SBT ) and analysis of the closest‐matching alleles from volunteer subjects from the B razilian B one M arrow D onor R egister ( REDOME , B razil). The new HLA alleles discovered include DRB 1*04:11:03, DRB 1*10:05, DRB 1*15:94 and DRB 1*16:22. Three of the novel alleles had single‐nucleotide substitution polymorphisms when compared to their most homologous allele. Of these, one harboured a single‐nucleotide polymorphism ( SNP ) identified as a silent substitution.