Premium
Polymorphisms in TREX 1 and susceptibility to HIV ‐1 infection
Author(s) -
Pontillo A.,
Girardelli M.,
Catamo E.,
Duarte A. J.,
Crovella S.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12071
Subject(s) - human immunodeficiency virus (hiv) , single nucleotide polymorphism , gene , coding region , biology , genetics , virology , immunology , genotype
Summary TREX ‐1 is a restriction factor against HIV ‐1. The coding sequence of TREX 1 gene was analysed in HIV + subjects searching for genetic variations possibly associated with the susceptibility to HIV infection. The single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX ‐1 in the anti‐ HIV response.