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TLR9 gene polymorphism (rs187084, rs352140): association with acute rejection and estimated glomerular filtration rate in renal transplant recipients
Author(s) -
Kim T. H.,
Jeong K.H.,
Kim S. K.,
Lee S. H.,
Ihm C. G.,
Lee T. W.,
Moon J. Y.,
Yoon Y. C.,
Chung J.H.,
Park S. J.,
Kang S. W.,
Kim Y. H.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12069
Subject(s) - transplantation , single nucleotide polymorphism , genotype , odds ratio , kidney transplantation , medicine , allele , immunology , renal function , biology , gastroenterology , gene , genetics
Summary The Toll‐like receptors ( TLR s) are related to innate immunity. TLR 9 , a member of TLR s, is expressed in immune cell–rich tissues and mediates cellular response. We investigated the association between TLR 9 polymorphisms and kidney allograft outcomes. To investigate whether TLR 9 polymorphisms are associated with acute rejection after renal transplantation, two single nucleotide polymorphisms ( SNP s) of TLR 9 gene (rs187084 ‐1486; rs352140, G2848A) were selected and genotyped by direct sequencing in 342 renal transplant recipients. SNPS tats, SNPA nalyzer, H elixtree and H aploview version 4.2 were used to analyse genetic data. Multiple logistic regression models (codominant, dominant, recessive and log‐additive) were used to evaluate odds ratios ( OR s), 95% confidence intervals ( CI s) and P values. Both SNP s, TLR 9 rs187084 ‐1486 and rs352140 G 2848A, of recipients were associated with the risk of acute rejection in renal transplantation. C allele of rs187084 ‐1486 and A allele of rs352140 G 2848A were protective genotype for acute rejection (OR 0.6, 95% CI 0.40–0.92; P = 0.018, OR 0.64, 95% CI 0.42–0.98; P = 0.04, respectively). rs187084 ‐1486 CT and rs352140 G2848A GA genotype were associated with a lower eGFR after a year of renal transplantation. TLR 9 polymorphisms, rs187084 and rs352140, of recipients were associated with the risk of acute rejection in renal transplantation. The patients with rs187084 ‐1486 CT and rs352140 G2848A GA genotype showed a lower eGFR after a year of renal transplantation.