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Association of interferon‐alpha gene polymorphisms with chronic hepatitis B virus infection
Author(s) -
Kimkong I.,
Tangkijvanich P.,
Hirankarn N.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12055
Subject(s) - hepatocellular carcinoma , hepatitis b virus , genotype , allele , medicine , snp , gastroenterology , virus , interferon , single nucleotide polymorphism , alpha interferon , immunology , gene , biology , virology , genetics
Summary In this study, the association between the risk of chronic hepatitis B virus infection and the polymorphisms within promoter regions of IFN ‐α1 and five genes was explored. This association study was performed on 180 Thai patients with chronic HBV infection [hepatocellular carcinoma ( HCC ) = 65 and non‐ HCC = 115], 173 individuals with self‐limited HBV infection and 140 healthy controls. Our results showed that the A allele of ‐1823G/A SNP within IFNA 1 gene was significantly associated with an increased risk of chronic HBV infection as compared to healthy individuals and self‐limited HBV group [ OR (95% CI ) = 2.20 (1.51–3.19), P = 0.000014 and OR (95% CI ) = 1.61 (1.12–2.33), P = 0.0073, respectively]. The effect of A allele was similar to autosomal recessive in which the presence of AA genotype when compared to GG and GA conferred the OR of 2.79 (95% CI = 1.72–4.52, P = 0.85). By multifactor dimensionality reduction analysis, we found the interaction between IFNA 5 (‐2529) and IFNA 1 (‐1823) genes that gave the risk to chronic HBV infection, with the OR (95% CI ) of the high‐risk to low‐risk group was 2.79 (1.77–4.40), P < 0.0001. However, further study in functional significance is required.