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Identification of a novel HLA ‐B*27 allele, B*27:79 and the B*27 subtype polymorphism in the Hunan ethnic Han population of China
Author(s) -
Xie Y.,
Wang S.,
Zuo Z.,
Zhang G.,
Cao L.,
Li T.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12045
Subject(s) - allele , genetics , locus (genetics) , biology , single nucleotide polymorphism , allele frequency , microbiology and biotechnology , typing , gene , genotype
Summary This article describes a novel HLA ‐B*27 allele, HLA ‐B*27:79, which was identified in a Hunan Han ethnic individual of China by a PCR sequence‐based typing method. The new sequence has one nucleotide mutation at position 437(A→T) compared with the allele B*27:04:01. This nucleotide change causes an amino acid substitution from Aspartate (Asp) to Valine (Val) at codon 122. This is the first report of mutation at this position in the HLA ‐B locus. Then, we investigated the HLA ‐B*27 subtype polymorphism of the Hunan Han population, and the results showed that B*27:04, B*27:05 and B*27:06 are the predominant subtypes with the allele frequencies 0.97%, 0.26% and 0.10% respectively.