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16 th IHIW: Anti‐ HLA alloantibodies of the of I g A isotype in re‐transplant candidates
Author(s) -
Arnold M.L.,
Heinemann F. M.,
Horn P.,
Ziemann M.,
Lachmann N.,
Mühlbacher A.,
Dick A.,
Ender A.,
Thammanichad D.,
Fischer G. F.,
Schaub S.,
Hallensleben M.,
Mytilineos J.,
Hitzler W. E.,
Seidl C.,
Doxiadis I. I. N.,
Spriewald B. M.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12032
Subject(s) - isotype , medicine , immunology , human leukocyte antigen , antibody , antigen , immunoglobulin class switching , monoclonal antibody , b cell
Summary In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti‐ HLA alloantibodies of the I g A isotype using a modified microsphere‐based platform. Of the kidney recipients, nearly one‐third ( n = 237, 31%) had I g A alloantibodies. Mostly, these antibodies were found in sera that also harboured I g G alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, I g A anti‐ HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the I g G isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the I g A alloantibodies could be established for over half of the 237 patients with I g A alloantibodies ( n = 124, 52%). A further 58 patients had specificities against HLA ‐ C or HLA ‐ DP , for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that I g A alloantibodies occur in about one‐third of patients, about half of these antibodies being donor specific.