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Association between CCL2 haplotypes and knee osteoarthritis
Author(s) -
HulinCurtis S. L.,
Bidwell J. L.,
Perry M. J.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12015
Subject(s) - haplotype , osteoarthritis , association (psychology) , medicine , biology , genetics , genotype , psychology , gene , pathology , psychotherapist , alternative medicine
Summary We examined five single nucleotide polymorphisms ( SNP s) and reconstructed 5‐locus haplotypes of the CCL2 gene, in knee osteoarthritis ( OA ) cases and in controls. The CCL2 rs2857657 variant ( G ) allele was observed more frequently in female knee OA cases than in controls. One haplotype ( H 5) was observed exclusively in the control group ( f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA .