Association between   CCL2   haplotypes and knee osteoarthritis | Zendy

HulinCurtis S. L. | Zendy; Bidwell J. L. | Zendy; Perry M. J. | Zendy

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Association between CCL2 haplotypes and knee osteoarthritis

Author(s) -

HulinCurtis S. L.,

Bidwell J. L.,

Perry M. J.

Publication year - 2013

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12015

Subject(s) - haplotype , osteoarthritis , association (psychology) , medicine , biology , genetics , genotype , psychology , gene , pathology , psychotherapist , alternative medicine

Summary We examined five single nucleotide polymorphisms ( SNP s) and reconstructed 5‐locus haplotypes of the CCL2 gene, in knee osteoarthritis ( OA ) cases and in controls. The CCL2 rs2857657 variant ( G ) allele was observed more frequently in female knee OA cases than in controls. One haplotype ( H 5) was observed exclusively in the control group ( f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA .

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