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Two novel alleles at HLA ‐ B locus identified in two volunteer bone marrow donors by sequence‐based typing
Author(s) -
Frison S.,
Longhi E.,
Mantovani M.,
Malagoli A.,
Giuli A.,
Piccolo G.,
Poli F.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12011
Subject(s) - allele , human leukocyte antigen , genetics , typing , locus (genetics) , biology , antigen , microbiology and biotechnology , gene
Summary Two novel human leucocyte antigen ( HLA ) class I alleles have been identified in two Italian individuals. HLA ‐B*27:07:02 is identical to HLA ‐B*27:07:01 except for a nucleotide substitution at position 846 (A‐>G) resulting in a silent mutation. HLA ‐B*35:206 differs from the most similar allele, HLA ‐B*35:08:01, because of a single base mutation at position 149 (G‐>C) causing an aminoacidic change at codon 26 from Gly to Ala.