Two novel alleles at  HLA ‐ B  locus identified in two volunteer bone marrow donors by sequence‐based typing | Zendy

Frison S. | Zendy; Longhi E. | Zendy; Mantovani M. | Zendy; Malagoli A. | Zendy; Giuli A. | Zendy; Piccolo G. | Zendy; Poli F. | Zendy

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Two novel alleles at HLA ‐ B locus identified in two volunteer bone marrow donors by sequence‐based typing

Author(s) -

Frison S.,

Longhi E.,

Mantovani M.,

Malagoli A.,

Giuli A.,

Piccolo G.,

Poli F.

Publication year - 2013

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12011

Subject(s) - allele , human leukocyte antigen , genetics , typing , locus (genetics) , biology , antigen , microbiology and biotechnology , gene

Summary Two novel human leucocyte antigen ( HLA ) class I alleles have been identified in two Italian individuals. HLA ‐B*27:07:02 is identical to HLA ‐B*27:07:01 except for a nucleotide substitution at position 846 (A‐>G) resulting in a silent mutation. HLA ‐B*35:206 differs from the most similar allele, HLA ‐B*35:08:01, because of a single base mutation at position 149 (G‐>C) causing an aminoacidic change at codon 26 from Gly to Ala.

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