Discovery of the novel HLA ‐ DRB 1*04:05:14 allele in a T aiwanese unrelated haematopoietic stem cell donor by a sequence‐based typing method

Summary We report here a de novo HLA ‐ DRB 1*04 allele, DRB 1*04:05:14, discovered in a T aiwanese unrelated volunteer bone marrow stem cell donor by a sequence‐based typing method. In exon 2, the DNA sequence of DRB 1*04:05:14 is identical to the sequence of DRB 1*04:05:01 except the nucleotide at positions 321 where C is replaced by T (at codon 78; TAC → TAT ). Due to the silent mutation, the nucleotide substitution produced no amino acid variation in comparison with DRB 1*04:05:01. We assume DRB 1*04:05:14 was derived from DRB 1*04:05:01 via a point mutation. The probable HLA ‐ A , ‐ B and ‐ DRB 1 haplotype in association with DRB 1*04:05:14 may be deduced as A *11‐ B *55‐ DRB 1*04:05:14. We here report the T aiwanese ethnicity of DRB 1*04:05:14.