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Associations of the IL‐1F7 gene polymorphisms with rheumatoid arthritis in C hinese H an population
Author(s) -
Pei B.,
Xu S.,
Liu T.,
Pan F.,
Xu J.,
Ding C.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12007
Subject(s) - genotype , rheumatoid arthritis , allele , single nucleotide polymorphism , snp , medicine , polymorphism (computer science) , arthritis , gene polymorphism , allele frequency , immunology , gene , genetics , biology
Summary Our aim was to investigate whether genetic polymorphism of IL‐1F7 (rs3811047) was involved in the susceptibility to rheumatoid arthritis ( RA ) in C hinese H an population. Single nucleotide polymorphism ( SNP ) of IL‐1F7 gene (rs3811047) was analyzed in 184 unrelated C hinese H an patients with RA and 184 healthy controls by ligase detection reaction based on high temperature ligase detection reactions polymerase chain reaction ( LDR ‐ PCR ). There were no statistically significant differences in the genetic polymorphism (genotypes and allele frequencies) of IL‐1F7 (rs3811047) in the patients with RA compared with control. Although all of the clinical and laboratory measures were similar to each other among patients with different genotypes, RA patients carrying AA or AG genotypes had lower swollen joint count, swollen joint index, rest pain and health assessment questionnaire ( HAQ ) score than that in patients having GG genotype ( P < 0.05). These findings show that no evidence for the involvement of a pro‐inflammatory polymorphism in the IL‐1F7 in the susceptibility to RA in China. Patients carrying A allele had less severe disease activity than those not carrying this allele, suggesting that the A allele of IL‐1F7 gene (rs3811047) may have a protective effect on RA .