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Characterization of the novel HLA ‐ DQB 1*06:48 allele by group‐specific sequencing
Author(s) -
Foster L.,
Tate D.,
Poulton K.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12004
Subject(s) - human leukocyte antigen , allele , genetics , exon , biology , gene , hla dqb1 , nucleotide , single nucleotide polymorphism , microbiology and biotechnology , antigen , genotype
Summary HLA ‐ DQB 1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 ( GGG > AGG and AAG > AAC ) relative to HLA ‐ DQB 1*06:02:01 and HLA ‐ DQB 1*06:37. This results in amino acid differences ( G > R and K > N ) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoire.