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Identification of the novel HLA ‐B*40:221 allele in a Taiwanese hematopoietic stem cell donor using a sequence‐based typing method
Author(s) -
Yang K. L.,
Lee S. K.,
Lin P. Y.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12003
Subject(s) - hla b , genetics , typing , human leukocyte antigen , exon , biology , allele , sequence (biology) , hematopoietic stem cell , microbiology and biotechnology , haplotype , point mutation , mutation , stem cell , gene , haematopoiesis , antigen
Summary Using DNA sequence‐based typing method, we found a new HLA ‐B*40 variant, B*40:221, in a Taiwanese hematopoietic stem cell donor. The allele sequence of B*40:221 is identical to the sequence of B*40:01:01 in exons 2, 3 and 4 except the nucleotides at codon 265 ( GGG → AGG ). The sequence variation caused one amino acid exchange at residue 265 where Gly was replaced by Arg. The probable HLA ‐A, ‐B, ‐C, ‐ DRB 1 and ‐ DQB 1 haplotype in association with B*40:221 may be deduced as HLA ‐A*11:01‐B*40:221‐C*03:04‐ DRB 1*14:54‐ DQB 1*05:02. The generation of B*40:221 is thought as a result of a nucleotide point mutation involving B*40:01:01. Our discovery of B*40:221 increases the polymorphism of B*40 in Taiwanese.