Yogurt and Streptococcus thermophilus metabolites ameliorated telomere attrition in D‐galactose‐induced ageing mice and t ‐BHP‐challenged HepG2 cells
Author(s) -
Shan Shufang,
Zheng Tianli,
Zhang Chaoxiong,
Song Xuejiao,
Chen Jiayi,
Shi Ying,
You Jia,
Cheng Guo,
Xiong Jingyuan
Publication year - 2020
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.14502
Subject(s) - streptococcus thermophilus , ageing , oxidative stress , telomere , lactobacillus rhamnosus , arabinose , senescence , lactobacillus , antioxidant , chemistry , food science , fermentation , biology , microbiology and biotechnology , biochemistry , medicine , dna , xylose
Summary Antioxidant‐rich diets affect telomere length, an integrative marker associated with age‐related diseases. Yogurt exerts antioxidative capacity and is speculated to support healthy ageing. However, direct experimental evidence is missing. Here, the effects of yogurt and dairy‐fermenting bacteria on D‐galactose‐induced ageing mice and chemically challenged HepG2 cells were evaluated. Relative telomere length (RTL) in leucocyte and liver were significantly longer in yogurt (1.21 ± 0.07; 1.23 ± 0.11) and Streptococcus thermophilus group (1.18 ± 0.15; 1.13 ± 0.12). When t ‐BHP‐challenged HepG2 cells were treated with digested yogurt and S. thermophilus , the senescence index (13.67 ± 3.30; 19.67 ± 2.87) were lower and RTL (1.25 ± 0.11; 1.18 ± 0.10) were longer than the model. Antioxidative effects were observed for yogurt and S. thermophilus metabolites, whereas milk and Lactobacillus rhamnosus metabolites showed minimal influence on RTL and oxidative stress. In conclusion, this study showed that yogurt and S. thermophilus metabolites ameliorated telomere attrition in ageing mice and t ‐BHP‐challenged HepG2 cells, possibly by reducing oxidative stress.