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Camel milk regulates T‐cell proliferation to alleviate dextran sodium sulphate‐induced colitis in mice
Author(s) -
Cui Changwan,
Lu Yiping,
Yue Yuanyi,
Wu Si,
Wang Shuang,
Yu Miao,
Sun Zhengrong
Publication year - 2020
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.14434
Subject(s) - inflammatory bowel disease , colitis , medicine , immune system , adverse effect , therapeutic effect , ulcerative colitis , gastroenterology , dextran , pharmacology , cytokine , intestinal mucosa , immunology , disease , chemistry , biochemistry
Summary The incidence of inflammatory bowel disease ( IBD ) is increasing in China. Current clinical methods of treatment for IBD are accompanied by side effects, and thus, the search for effective therapeutic drugs with minimal adverse effects is necessary. In the present study, the effects of camel milk ( CM ) on dextran sodium sulphate ( DSS )‐induced acute and chronic colitis in a mouse model were investigated. The results showed CM effectively alleviated the injury induced by DSS to the colon mucosa and imbalance of immune cells in mice. However, treatment with CM significantly increased the body weight of mice and decreased the disease activity index ( DAI ), histopathological score, proliferation of Th17 cells and concentration of inflammatory cytokine IL ‐17. The results from the present study indicate CM possesses intestinal protective effects.