Premium
Emerging roles of bioactive peptides on brain health promotion
Author(s) -
Katayama Shigeru,
Nakamura Soichiro
Publication year - 2019
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.14076
Subject(s) - neuroprotection , cognitive decline , dementia , cognition , neuroscience , neurotrophic factors , medicine , synaptic plasticity , dysfunctional family , pharmacology , biology , bioinformatics , biochemistry , clinical psychology , disease , receptor
Summary Cognitive dysfunction is a major debilitating age‐related disorder. Natural dietary bioactive compounds with potential neuroprotective and brain health benefits, including the prevention of cognitive impairment and dementia, have received increasing attention. Because cognitive decline is thought to result from dysfunctional synaptic plasticity, the induction of neuroprotective proteins, including neurotrophic factors, protein chaperones, and antioxidant enzymes, by dietary bioactive compounds may help prevent age‐related cognitive decline. Phytochemicals and bioactive peptides have been demonstrated to have a preventive effect on cognitive decline in different animal models and in human studies. This review focuses on the in vivo effects of bioactive peptides on brain function and the expression of neuroprotective factors.