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Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats
Author(s) -
Lamba Heena,
Sabikhi Latha,
Aggarwal Dipesh,
Choudhary Urmila,
Reddi Srinu,
Kapila Suman,
Kapila Rajeev
Publication year - 2018
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.13637
Subject(s) - in vivo , bioavailability , herb , chemistry , cholesterol , pharmacology , feces , body weight , traditional medicine , biology , biochemistry , endocrinology , medicine , medicinal herbs , microbiology and biotechnology
Summary Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones , especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavailability of the herb guggul in in vivo rat model. The effect of the different diets with encapsulated and nonencapsulated guggul was evaluated and compared after 6 weeks, based on the final body weight and analysis of organs, serum and faeces of normal and hypercholesterolaemic (H) rats. It was evident from the results that double emulsion‐encapsulated guggul showed better control on weight of H rats (25.98% lower), inhibition of HMG CoA reductase (3.95 times less) activity and reduction in atherosclerotic index (47.2%), as compared to diet with unencapsulated guggul . Encapsulation of guggul also improved faecal excretion of bile acids, lipids and total cholesterol in H and normal rats.