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Fermented soy‐powder milk with Lactobacillus plantarum P1201 protects against high‐fat diet‐induced obesity
Author(s) -
Xie Chengliang,
Hwang Chung Eun,
Oh Cheol Kyu,
Yoon Nal Ae,
Ryu Jin Hyun,
Jeong Joo Yeon,
Roh Gu Seob,
Kim Hyun Joon,
Cho Gyeong Jae,
Choi Wan Sung,
Kang Sang Soo,
Cho Kye Man,
Lee Dong Hoon
Publication year - 2017
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.13434
Subject(s) - conjugated linoleic acid , chemistry , fatty acid synthase , steatosis , lipoprotein lipase , endocrinology , food science , adipose tissue , medicine , fatty acid , biochemistry , linoleic acid , biology
Summary Fermented soy‐powder milk (FSPM) with Lactobacillus plantarum P1201 contains more conjugated linoleic acid (CLA) and isoflavone aglycones compared with unfermented soy‐powder milk (UFSPM). In this study, the antiobesity effect of FSPM was investigated in a high‐fat diet (HFD)‐induced obesity model. Results showed that FSPM reduced the weight of body, body weight gain, liver and mesenteric white adipose tissue by 10.7%, 17.7%, 32.8% and 24.1%, respectively, compared with the HFD group. Meanwhile, FSPM suppressed the HFD‐induced increase of serum parameters such as total and low‐density lipoprotein, cholesterol, alanine transaminase, glucose and c‐peptide. To investigate how FSPM ameliorated obesity, several lipid metabolism and inflammation‐related genes in liver were analysed. FSPM significantly ameliorated HFD‐induced hepatic steatosis by down‐regulating peroxisome proliferator‐activated receptor gamma, lipoprotein lipase, fatty acid synthase, acetyl CoA carboxylase, adipocyte fatty acid‐binding protein, tumour necrosis factor alpha and interleukin 1 beta. Our results showed FSPM can protect against HFD‐induced obesity.