Premium
Impacts of Camellia kucha and its main chemical components on the lipid accumulation in 3T3‐L1 adipocytes
Author(s) -
Li Kai Kai,
Wong Hing Lok,
Hu Tianyong,
Zhang Cheng,
Han Xiao Qiang,
Ye Chuang Xing,
Leung Ping Chung,
Cheng Bao Hui,
Ko Chun Hay
Publication year - 2016
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.13236
Subject(s) - adipogenesis , camellia sinensis , caffeine , fatty acid synthase , chemistry , 3t3 l1 , lipid metabolism , biochemistry , mapk/erk pathway , food science , kinase , endocrinology , biology , gene , botany
Summary Camellia kucha, a wild tea plant with potent antioxidant potential, has been consumed as local beverage for a long history. It is featured for the presence of theacrine and low content of caffeine. Interestingly, compared with caffeine showed strong stimulant effect, theacrine showed sedation, hypnoses and promoting memory function. In this study, the anti‐adipogenic ability of Kucha tea ( KT ) and its main components were evaluated in mouse 3T3‐L1 cells. The results indicated that KT acted significantly to decrease lipid droplet accumulation. Moreover, KT decreased the expression of major transcription factors of adipogenesis pathway, such as PPAR γ and C/ EBP α. KT also decreased the mRNA and protein levels of fatty acid synthase, fatty acid translocase, steroylcoenzyme A desaturase‐1, lipoprotein lipase and acetyl‐CoA carboxylase‐1. Furthermore, KT suppressed the activation of ERK , p38 and JNK .