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Anti‐acetylcholinesterase, antidiabetic, anti‐inflammatory, antityrosinase and antixanthine oxidase activities of Moroccan propolis
Author(s) -
ElGuendouz Soukaina,
Aazza Smail,
Lyoussi Badiaâ,
Antunes Maria D.,
Faleiro Maria L.,
Miguel Maria G.
Publication year - 2016
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.13133
Subject(s) - propolis , tyrosinase , phenols , chemistry , hyaluronidase , xanthine oxidase , flavones , amylase , enzyme , acetylcholinesterase , traditional medicine , food science , biochemistry , chromatography , medicine
Summary Biological properties of Moroccan propolis have been scarcely studied. In the present work, the total phenols and flavonoids from 21 samples of propolis collected in different places of Morocco or 3 supplied in the market were determined, as well as the in vitro capacity for inhibiting the activities of acetylcholinesterase, α‐glucosidase, α‐amylase, lipoxygenase, tyrosinase, xanthine oxidase and hyaluronidase. The results showed that samples 1 (region Fez‐Boulemane, Sefrou city) ( IC 50 = 0.065, 0.006, 0.020, 0.050, 0.014 mg mL −1 ) and 23 (marketed) ( IC 50 = 0.018, 0.002, 0.046, 0.037, 0.008 mg mL −1 ) had the best in vitro capacity for inhibiting the α‐amylase, α‐glucosidase, lipoxygenase, tyrosinase and xanthine oxidase activities, respectively. A negative correlation between IC 50 values and concentration of phenols, flavones and flavanones was found. These activities corresponded to the generally higher amounts of phenols and flavonoids. In the same region, propolis samples have dissimilar phenol content and enzyme inhibitory activities.