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Antioxidant, enzyme inhibitory and antiproliferative activity of polyphenolic‐rich fraction of commercial dry ginger powder
Author(s) -
Sakulnarmrat Karunrat,
Srzednicki George,
Konczak Izabela
Publication year - 2015
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1111/ijfs.12889
Subject(s) - oxygen radical absorbance capacity , antioxidant , chemistry , food science , polyphenol , gingerol , enzyme , caco 2 , biochemistry , traditional medicine , dpph , cell , medicine
Summary Polyphenolic‐rich fraction obtained from locally produced dry ginger powder in Brahmaputra valley, India, and commercially available dry ginger ( Zingiber officinale ) rhizome powder consisted of [6]‐gingerol (41.9%), [6]‐shogaol (24.3%), 1‐dehydro‐6‐gingerdione (8.6%), [8]‐gingerol (7.2%), [10]‐gingerol (5.1%), [6]‐paradol (5.9%) and [4]‐gingerol (3.6%). Traces of methyl‐[6]‐gingerol and methyl‐[8]‐gingerol (both at 1.8%) were also detected. The fraction exhibited high antioxidant capacity [total phenolics ( TP ), ferric reducing antioxidant power ( FRAP ), oxygen radical absorbance capacity ( ORAC ) and cellular antioxidant activity ( CAA assay)], effectively inhibited isolated digestive enzymes (α‐glucosidase, pancreatic lipase and angiotensin converting enzyme) and inhibited the proliferation of colon ( HT 29; IC 50 of 1.06 ± 0.02 mg mL −1 ) and gastric ( AGS IC 50 of 1.29 ± 0.03 mg mL −1 ) adenocarcinoma cells, without affecting the proliferation of their nontransformed counterparts ( IC 50 > 2.0 mg mL −1 ). This case study demonstrates that locally produced and commercially available dry ginger powder from Brahmaputra valley, India, retains numerous food components that may enhance human health.