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Therapy of Adrenocortical Hydroxylase Deficiencies in Acne Vulgaris
Author(s) -
Rose Leslie I.,
Birnbaum Michael D.
Publication year - 1979
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.1979.18.5.386
Subject(s) - acne , medicine , hirsutism , cosyntropin , dermatology , prednisone , hyperandrogenism , adrenocorticotropic hormone , endocrinology , hormone , diabetes mellitus , insulin resistance , polycystic ovary
Twenty women with acne vulgaris who presented to a gynecologist's office with the complaints of hirsutism, infertility, menorrhagia, or oligomenorrhea were subjected to a 24‐hour cosyntropin (ACTH) infusion to detect partial 11‐ or 21‐adrenocortical hydroxylase deficiencies. All patients demonstrated enzymatic defects and were placed on prednisone therapy. The six patients with moderate acne either showed improvement of their acne or conceived. Of the 14 patients with mild acne, seven showed improvement of their acne or conceived; whereas, the remainder showed no improvement. Patients with acne and gynecologic signs and symptoms should be evaluated for the presence of 11‐ or 21‐adrenocortical hydroxylase deficiencies.