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Mapping signal transducer and activator of transcription (STAT) activity in different stages of mycosis fungoides and Sezary syndrome
Author(s) -
Olszewska Berenika,
Żawrocki Anton,
Lakomy Joanna,
Karczewska Joanna,
Gleń Jolanta,
Zabłotna Monika,
Malek Marta,
Jankau Jerzy,
Lange Magdalena,
Biernat Wojciech,
Nowicki Roman J.,
SokołowskaWojdyło Małgorzata
Publication year - 2020
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.15036
Subject(s) - mycosis fungoides , stat protein , stat , pathogenesis , stat5 , medicine , stat1 , stat3 , immunohistochemistry , downregulation and upregulation , jak stat signaling pathway , activator (genetics) , stat4 , transcription (linguistics) , pathology , immunology , cancer research , signal transduction , lymphoma , biology , gene , interferon , receptor , biochemistry , linguistics , philosophy , tyrosine kinase
Background Deregulation of signal transducer and activator of transcription (STAT) signaling is known to participate in the pathogenesis of cutaneous T‐cell lymphomas (CTCLs). However, published results regarding STAT expression in different stages of CTCLs are conflicting. The aim of the study was to define the pattern of STAT expression in skin and detect any differences between pruritic and nonpruritic patients but also different stages of disease. Methods Thirty‐nine skin biopsies from CTCL patients and 24 biopsies from healthy volunteers were taken. Immunohistochemical staining for STAT 3, 5a, 5b, and 6 was performed in formalin‐fixed paraffin‐embedded sections of mycosis fungoides (MF) and Sezary syndrome (SS) specimens. Results We found increased expression of STAT proteins in CTCL: MF and SS skin in comparison to the control group. STAT5 but also STAT6 and to a lesser extent STAT3 seems to be constitutively activated in MF and SS. Moreover, also downregulation of STAT5b protein in advanced‐stage CTCL appears to contribute to its pathogenesis. There were no significant associations between expression of STATs and pruritus severity. Conclusions Our results confirm the possible pathogenetic role of STATs in CTCL. STATs seem to be a promising target for new effective therapeutic agents in CTCL.