z-logo
Premium
The different faces of mycosis fungoides: results of a single‐center study
Author(s) -
Sidiropoulou Polytimi,
Nikolaou Vasiliki,
Marinos Leonidas,
Voudouri Dimitra,
Komini Elena,
Economidi Afroditi,
Rigopoulos Dimitris,
Stratigos Alexander
Publication year - 2020
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14735
Subject(s) - medicine , mycosis fungoides , dermatology , epidemiology , cutaneous lymphoma , retrospective cohort study , pathological , cohort , lymphoma , pathology
Background Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas. Apart from the predominant Alibert‐Bazin type, several clinicopathological variants of diverse prevalence and biological behavior have been described. Data on clinical and epidemiological aspects of MF clinical subtypes are still weak. Aim To outline the clinical and epidemiological profile of the different MF types in a large volume of Greek patients. Methods Retrospective analysis of 688 MF cases treated in our lymphoma clinic. Epidemiological, clinical, pathological, and immunohistochemical data were retrieved. Results Six‐hundred and thirty‐six patients (416 males, 220 females) were included. The mean age at diagnosis was 60.2 years; the mean duration of disease prior to diagnosis was 63.2 months. Early‐stage MF (I‐IIA) involved 475 cases (74.7%). The prevalent type was classical MF (68.5%), followed by folliculotropic (17%), poikilodermic (5.5%), and psoriasiform (4.7%) MF. Atypical MF lesions as the sole manifestation of folliculotropic mycosis fungoides (FMF) – alopecia areata‐like lesions ( n  = 10), keratosis pilaris‐like lesions ( n  = 9) or acneiform rash ( n  = 4) – were also observed. Both poikilodermic and folliculotropic subtypes mainly involved younger patients. A significant diagnostic latency concerning poikilodermic and psoriasiform MF cases was recorded. Only 23 (3.3%) cases were of juvenile onset, with classical and poikilodermic MF equally affecting this age group, closely followed by FMF. Conclusions Our study presents the whole clinical‐epidemiological spectrum of MF in a large Greek cohort. The high prevalence of atypical MF manifestations characterized by early onset and indolent clinical course stood out among our FMF sample.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here