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Catalase but not vitamin D receptor gene polymorphisms are associated with nonsegmental vitiligo in Northwestern Mexicans
Author(s) -
OchoaRamírez Luis A.,
DíazCamacho Sylvia P.,
BecerraLoaiza Denisse S.,
VerdugoNieto Lucía,
MuñozEstrada Víctor F.,
ServínVázquez Luis A.,
OsunaRamírez Ignacio,
RodríguezMillán José,
VelardeFélix Jesús S.
Publication year - 2019
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14508
Subject(s) - vitiligo , calcitriol receptor , haplotype , vitamin d and neurology , medicine , depigmentation , polymorphism (computer science) , gene polymorphism , immunology , gene , endocrinology , genotype , genetics , biology , dermatology
Background Vitiligo is an acquired pigmentation disorder characterized by melanocyte loss via autoimmune mechanisms triggered by oxidative stress. Gene polymorphisms in antioxidant enzymes and immunomodulators such as catalase ( CAT ) and vitamin D receptor ( VDR ), respectively, have been linked to vitiligo in European and Asian populations. Our aim was to evaluate the role of CAT and VDR gene polymorphisms as well as CAT and vitamin D in nonsegmental vitiligo in Northwestern Mexicans. Methods A total of 357 subjects, 173 nonsegmental vitiligo patients and 184 age‐gender matched healthy controls, were genotyped by PCR ‐restriction fragment length polymorphism. CAT activity was determined in 39 patients and in 39 controls and vitamin D (VitD) levels in 35 individuals per group. Results CAT 419 C/T gene polymorphism was not informative, ‐89 A/T was associated with risk ( P = 0.02), and 389 C/T conferred protection against vitiligo along with AT haplotype ( P < 0.01 in both cases). VDR Bsm I, Apa I, and Taq I gene polymorphisms were not associated with vitiligo, but Bsm I was more prevalent in patients with Koebner phenomenon ( P = 0.02). Serum CAT activity and VitD levels were lower in patients than in controls, but they showed no association with any vitiligo clinical characteristics neither with their gene polymorphisms. Conclusions Our results suggest a role for CAT gene polymorphisms in vitiligo susceptibility in the Mexican population and a lack of association with VDR gene polymorphisms.