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Insomnia and other sleep complaints in inflammatory versus noninflammatory skin disorders: An observational case‐control study
Author(s) -
Mostaghimi Ladan,
Hetzel Scott
Publication year - 2019
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14488
Subject(s) - medicine , psoriasis , odds ratio , observational study , insomnia , dermatology , case control study , logistic regression , sleep disorder , psychiatry
Background Sleep problems are common in patients with dermatologic disorders. However, it is unknown whether inflammatory skin disorders are associated with more sleep problems than noninflammatory skin disorders. Purpose To determine whether sleep problems occur more frequently in people with inflammatory skin disorders compared to noninflammatory skin disorders. Study design Observational case‐control study. Methods Patients with inflammatory skin disorders (psoriasis [ n = 17] and chronic eczema [ n = 30]) and noninflammatory skin disorders (nonmelanoma skin cancers [NMSC] [ n = 31]) were enrolled. Data collection occurred during a single visit. Statistical analysis of questionnaire results between groups utilized inverse propensity score weighted (IPSW) ANOVA and logistic regression models. Results Groups differed in mean (SD) age ( P < 0.001) and itch severity ( P < 0.001). Based on IPSW ANOVA models, the inflammatory group had significantly higher fatigue scores (mean [95% CI]; 32.0 [28.4–35.5]) than the noninflammatory group (25.5 [21.6–29.3]; P = 0.017). The inflammatory group odds of insomnia were significantly greater based on two definitions of insomnia, ISI ≥ 15 and PSSQ‐I, with odds ratios (95% CI) of 14.4 (2.16–525) and 4.82 (1.45–20.7), respectively. These results were consistent in comparisons between the three groups, with no difference between psoriasis and chronic eczema, but with chronic eczema, significantly more were affected than NMSC. Conclusions Patients with inflammatory skin disorders report significantly more fatigue and have higher odds of insomnia compared to patients with noninflammatory skin cancers.