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Giant basal cell carcinoma: clinical–histological characteristics of 115 cases
Author(s) -
VacaAguilera Martha R.,
GuevaraGutiérrez Elizabeth,
BarrientosGarcía Juan G.,
TlacuiloParra Alberto
Publication year - 2019
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14455
Subject(s) - medicine , basal cell carcinoma , basal (medicine) , head and neck , carcinoma , retrospective cohort study , basal cell , gastroenterology , pathology , surgery , insulin
Giant basal cell carcinoma ( GBCC ) is a tumor ≥5 cm in size, with aggressive biological behavior, that represents 1% of basal cell carcinomas ( BCC ), and studies regarding it are scarce. Our objective was to investigate the clinical–histopathological characteristics of GBCC and the risk factors associated with its development. Methods A retrospective study over 8 years included patients with the clinical and histopathological diagnosis of GBCC . Age, sex, localization, size, evolution time, risk factors, and histological variants were compared to conventional BCC . Descriptive and inferential statistics were used, and a value of P < 0.05 was considered statistically significant. Results Of 5958 patients with BCC , 115 (2%) of them corresponded to GBCC . The average patient age was 73 ± 11 years, and the male sex (52%) and localization on the head and neck (63%) predominated. Average tumor size was 6.6 ± 2.2 cm, evolution time was 96 ± 86 months, and high‐grade histological variants (51%) predominated. The group with GBCC had higher age ( P < 0.01), greater frequency in the male sex ( P = 0.01), longer evolution time ( P < 0.01); a greater prevalence of risk factors (24% vs . 16%, P = 0.01), antecedents of other types of cancer ( P = 0.03), and of burns ( P = 0.03); and a greater frequency of high‐grade histological variants (51% vs. 29%, P < 0.01). Conclusions This is the largest series of GBCC published to date. Findings are similar to those previously reported, although the prevalence found here was greater.