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Association of antioxidants and vitamin D level with inflammation in children with atopic dermatitis
Author(s) -
Daniluk Urszula,
Filimoniuk Aleksandra,
KowalczukKrystoń Monika,
Alifier Marek,
Karpińska Joanna,
Kaczmarski Maciej G.,
Lebensztejn Dariusz M.
Publication year - 2019
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14438
Subject(s) - medicine , atopic dermatitis , scorad , gastroenterology , white blood cell , eosinophil , immunoglobulin e , mean platelet volume , vitamin , immunology , complete blood count , platelet , antibody , asthma , dermatology life quality index , disease
Background Changing the resources of vitamin D and antioxidant nutrients may affect the course of allergic diseases. The aim of the study was to investigate the association between CoQ10, vitamin D, retinol, and α ‐tocopherol serum levels and severity of atopic dermatitis ( AD ) in children. Methods Twenty‐nine children with AD aged from 1 to 15 years were enrolled into the study. The severity of AD was categorized into mild or moderate (≤50 points in SCORAD – Scoring Atopic Dermatitis index) and severe (>50 SCORAD points). The control group was comprised of 22 children with negative history of allergy aged from 2 to 15. The serum measurements included vitamin D, retinol, α ‐tocopherol, CoQ10, C‐reactive protein ( CRP ), complete blood count ( CBC ), and total immunoglobulin E (IgE). Results Low vitamin D concentration (<20 ng/ml) was observed mainly in patients with severe AD (77.8%), compared to children with mild or moderate AD (25%) or the control group (31.8%). Concentration of retinol was decreased significantly in patients with severe AD (median 1.32 μ mol/l), compared to children with mild and moderate AD (median 1.66 μ mol/l), but not to the control. Among inflammatory markers, only the group with severe AD demonstrated significantly elevated platelet count ( PLT ), red blood cell distribution width ( RDW ), and eosinophil count ( EO ). Retinol level correlated with PLT ( R = −0.7; P = 0.003), white blood count ( WBC ) ( R = −0.54; P = 0.01), total IgE ( R = −0.51; P = 0.016), mean platelet volume ( MPV ) ( R = 0.51; P = 0.02), and also with a disease severity index, SCORAD ( R = −0.55; P = 0.007), whereas vitamin D level correlated only with MPV ( R = 0.61; P = 0.003). No significant changes were found in tocopherol and CoQ10 levels between groups. Conclusions Children with AD should be routinely tested for vitamin D deficiency, especially during disease exacerbation. Our results confirmed correlation of serum inflammatory markers with decreased concentration of vitamin A in children with AD . This finding, however, might be an effect of severe stage of disease and not only of inadequate intake of retinol in the diet.