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CD30‐positive cutaneous extranodal natural killer/T‐cell lymphoma: clinicopathological features and survival outcomes
Author(s) -
Lee Woo Jin,
Moon Ik Jun,
Shin Ho Jeong,
Won Chong Hyun,
Chang Sung Eun,
Choi Jee Ho,
Lee Mi Woo
Publication year - 2019
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14362
Subject(s) - medicine , lymphoma , pathology , natural killer cell , cd30 , natural history , cytotoxic t cell , biochemistry , in vitro , chemistry
Background The prognostic value of CD 30 expression in cutaneous extranodal natural killer/T‐cell lymphoma is controversial. Methods Clinicopathological features, survival outcomes, and prognostic implications of CD 30 were retrospectively analyzed in 55 patients with cutaneous extranodal natural killer/T‐cell lymphoma. We classified patients into (i) primary cutaneous extranodal natural killer/T‐cell lymphoma and (ii) cutaneous extranodal natural killer/T‐cell lymphoma secondary to nasal disease depending on the primary tumor site. Results CD 30+ cutaneous extranodal natural killer/T‐cell lymphoma was more common in patients with cutaneous extranodal natural killer/T‐cell lymphoma secondary to nasal disease than in those with primary cutaneous disease. CD 30+ cases were more likely to present nodular lesions or cellulitis‐like swelling than CD 30− cases. Histologically, CD 30+ cutaneous extranodal natural killer/T‐cell lymphoma predominantly comprised large tumor cells compared with CD 30− cases. However, the clinical morphology and tumor cell size were not associated with survival outcomes. CD 30 expression was associated with better survival outcomes in patients with cutaneous extranodal natural killer/T‐cell lymphoma secondary to nasal disease. Conclusion CD 30+ cutaneous extranodal natural killer/T‐cell lymphoma presented peculiar clinicopathological features and had more favorable disease course in patients with cutaneous dissemination from nasal disease.