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The use of electrochemotherapy in combination with immunotherapy in the treatment of metastatic melanoma: a focused review
Author(s) -
Goggins Clare A.,
Khachemoune Amor
Publication year - 2019
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14314
Subject(s) - electrochemotherapy , medicine , immunotherapy , melanoma , metastatic melanoma , electroporation , oncology , treatment modality , head and neck , cancer , head and neck cancer , chemotherapy , bleomycin , cancer research , surgery , biochemistry , chemistry , gene
Electrochemotherapy ( ECT ) is a treatment modality that combines low‐dose chemotherapy with electroporation, thereby enhancing cytotoxicity. ECT was first utilized in the treatment of metastatic head and neck cancer. Today it is used as a local treatment for the cutaneous and subcutaneous metastases of a variety of cancers, including melanoma. In addition, recent evidence indicates that ECT in combination with immunotherapy can lead to a systemic tumor response. This review aims to summarize the efficacy of ECT in the treatment of metastatic melanoma, with a specific focus on the combination of ECT with immunotherapy.