The use of electrochemotherapy in combination with immunotherapy in the treatment of metastatic melanoma: a focused review | Zendy

Goggins Clare A. | Zendy; Khachemoune Amor | Zendy

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The use of electrochemotherapy in combination with immunotherapy in the treatment of metastatic melanoma: a focused review

Author(s) -

Goggins Clare A.,

Khachemoune Amor

Publication year - 2019

Publication title -

international journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.677

H-Index - 93

eISSN - 1365-4632

pISSN - 0011-9059

DOI - 10.1111/ijd.14314

Subject(s) - electrochemotherapy , medicine , immunotherapy , melanoma , metastatic melanoma , electroporation , oncology , treatment modality , head and neck , cancer , head and neck cancer , chemotherapy , bleomycin , cancer research , surgery , biochemistry , chemistry , gene

Electrochemotherapy ( ECT ) is a treatment modality that combines low‐dose chemotherapy with electroporation, thereby enhancing cytotoxicity. ECT was first utilized in the treatment of metastatic head and neck cancer. Today it is used as a local treatment for the cutaneous and subcutaneous metastases of a variety of cancers, including melanoma. In addition, recent evidence indicates that ECT in combination with immunotherapy can lead to a systemic tumor response. This review aims to summarize the efficacy of ECT in the treatment of metastatic melanoma, with a specific focus on the combination of ECT with immunotherapy.

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