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Decrease of superficial serine and lactate in the stratum corneum due to repetitive frictional trauma
Author(s) -
Wong Lai San,
Otsuka Atsushi,
Tanizaki Hideaki,
omura Yumi,
Nakashima Chisa,
Yamamoto Yosuke,
Yen Yu Ta,
Rerknimitr Pawinee,
Honda Tetsuya,
Kabashima Kenji
Publication year - 2018
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13856
Subject(s) - stratum corneum , medicine , dermatology , stratum , pathology , paleontology , biology
Background Repetitive frictional trauma can be induced in daily and occupational activities, such as daily ablutions with washcloths. The influence of frictional trauma on the skin barrier function, especially in the perspective of the components of stratum corneum ( SC ), has not yet been studied in detail. Raman spectroscopy is a noninvasive optical technique based on inelastic light scattering that is capable of measuring several components in the skin. In this study, we used Raman spectroscopy to investigate the change in natural moisturizing factor ( NMF ) components in the SC following repetitive physical friction. Methods Six healthy volunteers, who were included in the study after obtaining an informed consent, performed repetitive washing with soap using nylon towels on the forearm twice a day for 2 weeks and used Raman spectroscopy to investigate the change in NMF components in the SC . Results Compared with the control, which was washed with soap at the same frequency on the opposite forearm, a significant increase in the transepidermal water loss ( TEWL ) and a decrease in NMF , serine, and total lactate, responsible for maintenance the SC hydration and structuring and maintaining the epidermal barrier function, in the SC were found. Conclusions Increased TEWL and decreased NMF are considered as an etiology of atopic dermatitis ( AD ); therefore, our findings provide evidence that daily activities with repetitive frictional trauma may be related to the predisposition of AD .