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A case‐control study on the association of pulse oral poliomyelitis vaccination and Gianotti‐Crosti syndrome
Author(s) -
Zawar Vijay,
Chuh Antonio
Publication year - 2017
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13451
Subject(s) - medicine , poliomyelitis , referral , pediatrics , vaccination , immunization , family medicine , immunology , antibody
Background Since 1995, the Indian government has been launching two National Immunization Days ( NIDs ) annually to administer oral polio vaccines ( OPVs ) to children under the age of 5. Our aim was to investigate the association between OPVs and Gianotti‐Crosti syndrome ( GCS ). Methods A board‐certified dermatologist in solo practice conducted the examinations. The patients consulted without the need of a referral. We retrieved files of all children under the age of 5 who were diagnosed with GCS in 18 months. There were three NIDs during these months. We charted the number of children 1 month before, 1 week before, 1 week after, and 1 month after the three NIDs . Results A total of 116 children (49 boys and 67 girls) under the age of 5 with GCS were found (average age: 2.9 years) within these 18 months of three NIDs . Eleven (9.5%) and 105 (90.5%) children developed GCS 1 month before and 1 month following OPV administration, respectively (RR: 1.81; 95% CI: 1.40–2.35; P < 0.0001). Three (2.6%) and 58 (50.0%) children developed GCS 1 week before and 1 week after OPV administration, respectively ( RR : 1.90; 95% CI: 1.12–3.22; P < 0.0001). Conclusions The administration of OPV is significantly associated with the occurrence of GCS in the part of the world that we investigated. As we demonstrated a temporal relationship, this association is likely to be causal.