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Association of classic lichen planus with human herpesvirus‐7 infection
Author(s) -
Nahidi Yalda,
Tayyebi Meibodi Naser,
Ghazvini Kiarash,
Esmaily Habibollah,
Esmaeelzadeh Maryam
Publication year - 2017
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13416
Subject(s) - pathogenesis , mucocutaneous zone , immunology , etiology , medicine , immune system , disease , virus , oral lichen planus , polymerase chain reaction , dermatology , pathology , biology , gene , genetics
Background Lichen planus is a mucocutaneous papulosquamous itchy disease with unknown etiology. A number of factors such as immune mechanisms, viral agents, and drugs have been implicated in pathogenesis of lichen planus. In recent years, several studies have indicated the role of viral agents in this disease, including human herpesvirus‐7 ( HHV ‐7). Studies have given contradictory results, which is why we decided to study the possible association between lichen planus with HHV ‐7. Methods In this case–control study, which was conducted on 60 cutaneous classic lichen planus samples as well as 60 healthy control skin samples after matching the two groups in terms of gender and age, tissue samples of patients and controls were studied by real time polymerase chain reaction to detect for HHV ‐7. Results According to this study, HHV ‐7 DNA was found in 18 samples of the case group (30.0%) and in six (10.0%) of the control group ( P = 0.006). Conclusion The results of this study support the likely role of HHV ‐7 in pathogenesis of lichen planus. As an exogenous antigen, this virus may be involved in cellular immune‐mediated destruction of keratinocytes.